Chapter 3 Biopharmaceutics and Pharmacokinetic Introduction

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Multiphasic Drug Elimination?

redrawn from Smith et al., 1973

Figure 3.27.1 Slide of pentobarbital plasma concentration versus time illustrating the multiphasic distribution pattern. From a plasma concentration time curve it may appear that this drug is rapidly eliminated from the body. Actually little of the drug is eliminated with much of it being distributed in various tissues of the body. Here distribution is a major factor affecting the overall kinetics of this drug. By looking further we can see the real picture.

References

Smith, R.B., Dittert, L.W., Griffen Jr., W.O., and Doluisio, J.T. 1973 Pharmacokinetics of Pentobarbital after Intravenous and Oral Administration, J. Pharmacokin. Biopharm., 1, p5

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