Basic Pharmacokinetics
School of Pharmacy
University of Wisconsin-Madison

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Course Description

Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.

Application of biopharmaceutical and pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients

Course Objectives

Students will be able to:

Demonstrate an understanding of the differential and integrated equations associated with pharmacokinetic models
Demonstrate an understanding and assess factors which affect the absorption, distribution, metabolism and excretion of drugs
Calculate parameter values from appropriate data using graphical techniques
Calculate appropriate dosing regimens using appropriate criteria
Describe the techniques used to determine drug concentrations in biological and formulation matrices

Instructor: Sin Yin (Sean) Lim, PharmD, MS

E-mail Address

sinyin.lim@wisc.edu

Course Maintenance

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Textbook and Related Resources

David Bourne, Basic Pharmacokinetics

Other Textbooks - online list of pharmacokinetic text

Homework Sets

Homework Set #1 [AUC Calculation Using the Trapezoidal Rule] Chapter 2
Homework Set #2 [Calculate One Compartment Parameters] Chapter 4
Homework Set #3 [Intravenous Infusion] Chapter 6 – first problem
Homework Set #4 [Intravenous Infusion] Chapter 6 – second problem
Homework Set #5 [Intravenous Infusion] Chapter 6 – third problem
Homework Set #6 [Method of Residuals] Chapter 9
Homework Set #7 [Calculation of F] Chapter 9
Homework Set #8 [Multiple IV Bolus 1] Chapter 14
Homework Set #9 [Aminoglycoside - Steady State Dosing]
Homework Set #10 [Hepatic Clearance Calculations] Chapter 17
Homework Set #11 [Renal Pharmacokinetics]
Homework Set #12 [Non-linear Elimination Kinetics] Chapter 21

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Basic Pharmacokinetics School of Pharmacy University of Wisconsin-Madison