Coursework

1. Introduction
2. Background Material
   • exponents and logarithms, calculus, differentiation and integration
   • use of spreadsheets
   • spectroscopic drug analysis
3. Pharmacokinetics introduction
4. One compartment I.V. bolus
   Plasma data
   Volume, AUC, Half- life
5. Analysis of Urine data, plot types, clearance, metabolism, renal function
6. Intravenous infusion
   Steady state concentration, slow- fast infusion, post infusion
7. Routes of drug administration
8. Pharmacokinetics of oral administration
   Method of residuals, W- N method
9. Bioavailability calculations
10. Bioavailability studies, statistics
11. Physiological factors affecting oral absorption
12. Physical-Chemical factors affecting oral absorption
13. Formulation factors affecting oral absorption
14. Multiple Bolus I.V. dose administration
15. Multiple Oral Dose Administration
16. Routes of excretion
17. Metabolism
18. Drug distribution
19. Multi-compartmental pharmacokinetic models
20. Non-linear pharmacokinetic models
21. Clinical Applications of Pharmacokinetics

Copyright 2001 David W.A. Bourne