Pharmacokinetics and Biopharmaceutics
PHAR 7632 (Revised)
This website
http://www.boomer.org/c/p4/
This course and more is available on CD
Course Description
Pharmacokinetics and Biopharmaceutics PHAR 7632 (Revised)
Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.
Application of biopharmaceutical and pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients
Official Course Description
Biopharmaceutics (PHAR 7632)
Factors affecting absorption, distribution, metabolism, and excretion of drugs; routes of drug absorption, metabolism, and excretion; bioequivalence and drug product testing.
Pharmacokinetics (PHAR 7633)
Quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs; derivation of mathematical models to calculate the time course of drug and metabolite concentrations following drug administration; analysis of drug concentration data sets graphically and using non-linear regression.
Course Objectives
Students will be able to:
- Use the differential and integrated equations associated with drug pharmacokinetics; this includes determination of parameter values and the development of drug dosage regimens
- Understand and assess factors which affect the absorption, distribution, metabolism and excretion of drugs
- Understand the techniques used to determine drug concentrations in biological and formulation matrices
Instructor: David W.A. Bourne, Ph.D.
Office
CPB 303
No set office hours, drop by (not too early) or set-up a time in class or by email or IM.
I usually keep my door open when I am in my office. You are welcome to come in and ask for help. I can usually stop what I am doing within a few minutes. If the door is closed I might be away for a few minutes only or longer. Feel free to wait for a few minutes. I might be on the phone and not able to help, usually this would only be a few minutes also. Feel free to wait for a few minutes.
E-mail Address
- david-bourne@ouhsc.edu (if the campus network or email is down this email address is probably also unavailable - some delays of a few hours are common)
- david@boomer.org (if the course website is down this email is probably also unavailable)
Instant Message (IM) Screen Name:
Exam Schedule
Course Maintenance
Textbook and Related Resources
Required TEXT - None required. The websites p4, p3, and pkin should be useful.
Recommended Calculator - The College has purchased Sharp Model EL-501V calculators in OKC and Canon F-603 calculators in Tulsa for student use during PHAR 7632 exams. You may wish to buy the same calculator to practice on or you could borrow one briefly from Student Services.
References text - see the online list of pharmacokinetic text
- Introduction to the Course - Online Resources
- Background Mathematical Material
- Pharmacokinetic Introduction
- One Compartment IV Bolus
- Analysis of Urine Data
- Intravenous Infusion
- Routes of Drug Administration
- Pharmacokinetics of Oral Administration
- Calculation of Bioavailability Parameters
- Bioavailability Studies
- Physiological Factors Affecting Oral Absorption
- Physical-Chemical Factors Affecting Oral Absorption
- Formulation Factors
- Multiple IV Bolus Dose Administration
- Multiple Oral Dose Administration
- Routes of Excretion
- Metabolism
Above for PHAR 7632
Summer Break
Below for PHAR 7633
- Drug Distribution
- Multi-Compartment Pharmacokinetic Models
- Noncompartmental Analysis
- Non-Linear Pharmacokinetic Models
- Non-Linear Regression Analysis of Pharmacokinetic Data
- Pharmacodynamic and Physiologically Based Pharmacokinetic Models
- Pharmaceutical Analysis
- Clinical Applications of Pharmacokinetics
Video PODcast snippets as a RSS Feed (works with Safari - may not work under Windows) or Open iTunes and select 'Advanced:Subscribe to Podcast..." then paste in the URL: http://www.boomer.org/c/snips/phar7632.xml
Homework Sets
Course Policies
Class will meet twice per week for lecture/tutorial/help sessions. Attendance at all class sessions is not required but is encouraged. Students will need to read ahead and be ready to understand and ask about material during class time. Some problems may be worked during class and it would be a help if student brought their calculator to class. Lecture material will be taken directly from the course website.
| First Exam |
30% |
| Second Exam |
30% |
| Final Exam |
30% |
| Homework |
10% |
| Total |
100% |
Exam and homework policies
To maintain parity between the two campuses there will be no content questions allowed during the exam. If you think there is a problem with a question you may write a short (one sentence) explanation of the problem for consideration by the grader. Show all work, as partial credit will be given. The student is only allowed to have a pen, pencil, and eraser with them during the exam. A standard calculator (Sharp EL-501V) and a ruler will be provided to each student for use in the exam. Coats, jackets, hats (including ball caps), calculators, Palm and other PDA devices, computers, cell phones, pagers, papers, backpacks, briefcases, etc, MUST be placed at the front of the classroom prior to the exam start. Students who leave the exam room during the exam will not be allowed to re-enter the room until the last student has completed their exam. The exam will be returned after grading and may be reviewed in class. Any and all questions about the exam grade must be resolved within two weeks of your receiving the graded exam. A make-up exam may be available on request with a suitable excuse. The instructor will decide the schedule for any make-up exam. The final exam will be retained by the instructor but will be available for review by request. A make-up exam may be available on request with a suitable excuse. Because of end of semester scheduling this will result in an incomplete (I) grade being awarded. The incomplete will be changed to a letter grade after the completion of the course requirements.
You may work on the homework with the help of your colleagues and/or your instructor; however, you must turn in your own effort for credit. Many of the homework exercises will be submitted on-line. You may repeat these on-line homework sets to improve your grade but this will involve redoing the exercise with new data. Homework that is turned in to the instructor will be returned after grading. Homework may be reviewed in class. Any and all questions about the homework grade must be resolved within one week of the graded homework being returned. Homework must be turned in on time for full credit.
| Grade |
Total (%) |
| A |
100 - 90 |
| B |
90 - 80 |
| C |
80 - 70 |
| D |
70 - 60.0 |
| F |
less than 60 |
Academic Misconduct
Students are expected to work independently during all exams. Any use of resources other than your own recollection and reasoning ability on an individual exam is cheating. If you are suspected of any of the above or other forms of academic dishonesty, you will be reported to the College of Pharmacy Dean's Office with subsequent actions based on University regulations and policies. [http://www.admissions.ouhsc.edu/Admin/amc.htm] Generally a grade of zero will be awarded for the exam in which cheating is proven.
Scheduled Class Meeting Time
- Class Meeting Time (PHAR 7632): Monday and Thursday in CPB 103 and SAC ID18 at 10:00 am to 10:50 am
The class is being presented simultaneously to two classrooms (one class), one in Oklahoma City (OKC) and the other in Tulsa. I anticipate that all the classroom material will originate in Oklahoma City, CPB 103. Since I am essentially the only instructor in PHAR 7632 the content and length of classroom sessions can be flexible.
Consequently:
- If a class does finish early (that is no more new material) I will usually be available to fill in the allocated time with questions and answers via video conference 'far end' (distant) or with 'near end' (local) students.
- If there is a network (or other computer) problem I will not cover new material during the downtime. If the breakdown is during the first part of the class time we may be able to get back up for the rest of the time. If the break is towards the end of class time I will probably abandon the class for new material, reverting to answering questions from local students.
- Two screens. I was going to comment that I will tend to use the west screen and essentially ignore the east screen, however, since these lectures are presented by video conference I will try to ignore both large screens in OKC and use the computer monitor or overhead to emphasize material.
- OKC Microphones. Since the sound from the microphones in OKC are output via the speakers at the front, side of the room please try to identify yourself by raising or waving your hand if you want me to see where you are sitting. It might seem clumsy but you might identify where you are, that is, OKC or Tulsa.
- Attendance. There are no points awarded or penalties assessed in relation to attendance in this class. Most of the material is available on the website. If you are unable to attend class for any reason please ask your class colleagues for information about the material covered. If you need help understanding any material in this class please review the online material, your notes, or ask the instructor during or after class, in the instructors's office, by email or by IM (see above). Lecture material will be presented only once and will not be available by any streaming or storage medium so if you need to ask questions as the material is presented please plan to attend lectures in OKC or Tulsa. If class is cancelled or class time is changed I will try to let you know as soon as possible by email. Please ensure that I have a record of your correct email address.
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