Pharmacokinetics and Biopharmaceutics
This website: https://www.boomer.org/c/p4/
The eBook: Basic Pharmacokinetics and other eBooks for the iPad®
and Apps for the iPhone®, iPad® and AppleTV®
Course Description
Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.
Application of biopharmaceutical and pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients
Course Objectives
Students will be able to:
- Demonstrate an understanding of the differential and integrated equations associated with pharmacokinetic models
- Demonstrate an understanding and assess factors which affect the absorption, distribution, metabolism and excretion of drugs
- Calculate parameter values from appropriate data using graphical techniques
- Calculate appropriate dosing regimens using appropriate criteria
- Describe the techniques used to determine drug concentrations in biological and formulation matrices
Instructor
- David W.A. Bourne, B.Pharm., Ph.D.
E-mail Address
Textbook and Related Resources
David Bourne, Basic Pharmacokinetics
Other Textbooks - online list of pharmacokinetic text
- Online Resources
- Background Mathematical Material
- Pharmacokinetic Introduction
- One Compartment IV Bolus
- Analysis of Urine Data
- Intravenous Infusion
- Routes of Drug Administration
- Pharmacokinetics of Oral Administration
- Calculation of Bioavailability Parameters
- Bioavailability Studies
- Physiological Factors Affecting Oral Absorption
- Physical-Chemical Factors Affecting Oral Absorption
- Formulation Factors
- Multiple IV Bolus Dose Administration
- Multiple Oral Dose Administration
- Routes of Excretion
- Metabolism
- Drug Distribution
- Multi-Compartment Pharmacokinetic Models
- Noncompartmental Analysis
- Non-Linear Pharmacokinetic Models
- Pharmacodynamic and Physiologically Based Pharmacokinetic Models
- Pharmaceutical Analysis
- Clinical Applications of Pharmacokinetics
- Non-Linear Regression Analysis of Pharmacokinetic Data
- Integrating Differential Equations using Laplace Transforms
- Numerical Integration
- Optimization Methods
- Weighting Data
- Selection of the "Best" Model
- Identifiability
- Optimal Sampling
Homework Sets
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