Basic Pharmacokinetics

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Course Description

Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.

Application of biopharmaceutical and pharmacokinetic theory to clinical problems involved in optimizing and monitoring drug use in patients

Course Objectives

Students will be able to:

Instructor: David W.A. Bourne, B.Pharm., Ph.D.

E-mail Address

Textbook and Related Resources

David Bourne, Basic Pharmacokinetics

Other Textbooks - online list of pharmacokinetic text

A Course Outline

  1. Online Resources
  2. Background Mathematical Material
  3. Pharmacokinetic Introduction
  4. One Compartment IV Bolus
  5. Analysis of Urine Data
  6. Intravenous Infusion
  7. Routes of Drug Administration
  8. Pharmacokinetics of Oral Administration
  9. Calculation of Bioavailability Parameters
  10. Bioavailability Studies
  11. Physiological Factors Affecting Oral Absorption
  12. Physical-Chemical Factors Affecting Oral Absorption
  13. Formulation Factors
  14. Multiple IV Bolus Dose Administration
  15. Multiple Oral Dose Administration
  16. Routes of Excretion
  17. Metabolism
  18. Drug Distribution
  19. Multi-Compartment Pharmacokinetic Models
  20. Noncompartmental Analysis
  21. Non-Linear Pharmacokinetic Models
  22. Non-Linear Regression Analysis of Pharmacokinetic Data
  23. Pharmacodynamic and Physiologically Based Pharmacokinetic Models
  24. Pharmaceutical Analysis
  25. Clinical Applications of Pharmacokinetics

Homework Sets

This page was last modified: Wednesday, 15th Jul 2020 at 5:38 pm

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